Buy PNC 27 Peptide

PNC 27 is a peptide designed to target and destroy cancer cells by inducing necrosis specifically in malignant cells while sparing healthy tissues. Its mechanism involves binding to the p53 protein and interacting with the cancer cell’s membrane, effectively triggering cell death. This peptide has garnered attention in research for its precision and potential as a non-toxic therapeutic option in oncology.

Sale!
PNC-27 Pre-Mixed Pen 5mg
£106.67 – £288.01 Select options This product has multiple variants. The options may be chosen on the product page
Sale!
PNC-27 Peptide Vial
£104.09 – £113.07 Select options This product has multiple variants. The options may be chosen on the product page
Sale!
PNC-27 Nasal Spray
£112.09 – £219.18 Select options This product has multiple variants. The options may be chosen on the product page

PNC 27 Peptide Products

PNC 27 Netherlands is a well researched peptide. PharmaGrade.Store is committed to supplying the research industry with high purity PNC 27 products including:

- PNC 27 Peptide Vial – PNC 27 supplied in a sterile glass vial, ready for peptide reconstitution. Please note you also require bacteriostatic water when reconstituting your peptide.
  PNC 27 is available in 5mg peptide vials.
- PNC 27 Peptide Nasal Spray – a ready to use peptide solution for administration Choose from 15 ml or 30ml PNC 27 nasal sprays here.
- PNC 27 Pre-Mixed Peptide Pen – High purity PNC 27 peptide pre-mixed with Bac Water and ready to use. Buy PNC 27 5mg Pre-Mixed Pen here.

Mechanism of Action PNC 27 Netherlands

PNC 27 is a peptide that uniquely targets and eliminates cancer cells by leveraging the tumour-suppressing properties of the p53 protein [1]. Its primary mechanism involves binding to a peptide-binding domain in the p53 protein, which is often mutated in cancer cells. Once bound, PNC 27 effectively restores the tumor-suppressive functions of p53, which is typically rendered inactive in malignant cells [2].

A key step in its action is its selective binding to cancer cell membranes through an interaction with HDM-2, a protein overexpressed in cancer cells. This binding disrupts the integrity of the cancer cell’s membrane, leading to necrosis without harming healthy cells [3].

Unlike conventional cancer treatments, PNC 27 is non-toxic and highly specific, making it an innovative approach that minimizes collateral damage while effectively inducing cancer cell death. This targeted mechanism offers great potential for safer and precise anti-cancer therapies.

PNC 27 Potential Benefits

Netherlands Clinical studies are ongoing into the potential benefits and applications of PNC 27, however preliminary findings suggest it may:

Cancer targeting: PNC 27 may target cancer cells by inducing necrosis specifically in malignant cells while sparing healthy tissues [2].
May suppress tumours –Reactivates the tumour-suppressing functions of the p53 protein, often mutated in cancer cells [1] [3].
Cell targeting –Demonstrates high specificity, reducing the risk of damage to non-cancerous cells [4].
Potential safer profile –Non-toxic and potentially offering less side-effects compared to traditional chemotherapy or radiation therapies [5].
Precise mechanism of action – Utilizes selective binding through HDM-2 protein, which is overexpressed in cancerous cells, for precise targeting [2].

Research on PNC-27 Netherlands

Netherlands Scientific research on PNC 27 peptide has highlighted its effectiveness in targeting cancer cells by exploiting the mutated p53 protein commonly found in malignancies. Studies demonstrate that PNC 27 binds to the p53 protein and disrupts cancer cell membranes via HDM-2 interaction, leading to selective necrosis of cancer cells while sparing healthy tissues [2]. Experimental results show promising anti-cancer properties, with high specificity and minimal toxicity.

Ongoing research focuses on furthering its clinical applications, assessing its efficacy across various cancer types, and testing its compatibility with existing treatments. PNC 27’s unique mechanism positions it as a potential breakthrough in oncology.

PNC-27 Specifications:

View PharmaGrade Store Netherlands PNC-27 HPLC Certificate here.

Amino Acid Sequence: Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH

Molecular Formula: C188H293N53O44S

Molecular Weight: 4031.7 g/mol

Buy PNC 27 Peptide Netherlands for research use from PharmaGrade.Store.

Frequently Asked Questions about BPC-157 Peptide Netherlands

Is BPC-157 peptide legal?

BPC-157 peptide is classed as a research chemical is not currently approved by the FDA for human use and is typically sold for testing and laboratory experimentation only. It’s important to check the legal status of BPC-157 in your specific region or consult with a healthcare professional for guidance on its use.

Is BPC-157 safe?

Although BPC-157 has shown promising results in Netherlands preclinical studies and is generally considered safe with minimal reported side effects it is not yet approved for human use and remains classed as research chemicals.

Where can I buy lab tested BPC-157 Peptide?

PharmaGrade.Store Netherlands supplies high purity research peptides. All peptides are subject to HPLC Purification and Mass Spec Analysis.

What are the side effects of BPC-157?

BPC-157 peptide appears to have minimal side effects based on the results of current research studies, with few reported adverse reactions. However, as with any supplement or peptide, individuals may experience mild gastrointestinal discomfort, headaches, or dizziness, although these side effects are not commonly observed.

Do peptide nasal sprays work?

Peptide nasal sprays have gained interest for their potential to deliver peptides directly to the nasal mucosa for systemic effects. While some studies suggest that peptide nasal sprays may be effective in certain applications such as promoting cognitive function or immune support, more research is needed to fully understand their efficacy and safety in various health contexts.

Blogs:

The Link Between Triptorelin Peptide and Cancer Research

This blog discusses the significant role of Triptorelin peptide in cancer research, particularly its potential in treating hormone-dependent cancers like prostate and breast cancer. Triptorelin functions as a gonadotropin-releasing hormone (GnRH) agonist, effectively suppressing hormone production, which is crucial in slowing cancer growth. The article highlights its mechanism of action, clinical applications, and the promising results from various studies.

It also addresses the benefits and challenges of using Triptorelin in cancer therapy, emphasizing its potential to enhance treatment outcomes when combined with other therapies. The blog underscores ongoing research and future prospects in oncology.

Explore the future of cancer therapy

P-21 Peptide Therapy: The Future of Cancer Treatment

Explore the promising potential of P-21 peptide therapy in cancer treatment and cellular health. It highlights how P-21 peptides target cancer cells by disrupting cell division and promoting healthy cell growth, offering a more precise approach compared to traditional therapies.

The article delves into the science behind P-21, its applications in oncology, and its broader benefits in enhancing cellular health, including regenerative medicine and anti-aging.

It also discusses ongoing research, future prospects, and the ethical considerations of integrating P-21 therapy into healthcare, emphasizing its role in advancing personalized medicine.

Read about P-21 and similar peptides

Scientific Research:

[1] Krzesaj P, Adler V, Feinman RD, Miller A, Silberstein M, Yazdi E, Pincus MR. Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing Mitochondrial Disruption. Ann Clin Lab Sci. 2024 Mar;54(2):137-148.

[2] Davitt K, Babcock BD, Fenelus M, Poon CK, Sarkar A, Trivigno V, Zolkind PA, Matthew SM, Grin’kina N, Orynbayeva Z, Shaikh MF, Adler V, Michl J, Sarafraz-Yazdi E, Pincus MR, Bowne WB. The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells. Ann Clin Lab Sci. 2014 Summer;44(3):241-8.

[3] Sarafraz-Yazdi E, Bowne WB, Adler V, Sookraj KA, Wu V, Shteyler V, Patel H, Oxbury W, Brandt-Rauf P, Zenilman ME, Michl J, Pincus MR. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1918-23.

[4] Thadi A, Lewis L, Goldstein E, Aggarwal A, Khalili M, Steele L, Polyak B, Seydafkan S, Bluth MH, Ward KA, Styler M, Campbell PM, Pincus MR, Bowne WB. Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. Anticancer Res. 2020 Sep;40(9):4857-4867.

[5] Sahar Taghavi, Mahsa Shahriari, Khalil Abnous, Seyed Mohammad Taghdisi, Mona Alibolandi, Mohammad Ramezani, Development of PNC-27 targeted codelivery system for survivin-shRNA and SN38 against colon adenocarcinoma in vitro and in vivo, Journal of Drug Delivery Science and Technology, Volume 69, 2022, 103180

Buy PNC-27 Netherlands Today from PharmaGrade.Store

ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY

DISCLAIMER: All products sold by PharmaGrade.Store are for research and laboratory use only. These products are not designed for use or consumption by humans or animals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such. By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals