Buy SS-31 Peptide

SS-31 peptide, is a small, cell-permeable peptide designed to target and stabilize mitochondrial membranes. It plays a crucial role in reducing oxidative stress by interacting with cardiolipin, a key component of mitochondrial structure, enhancing energy production, and preventing cell damage. Researchers are exploring its therapeutic potential in treating mitochondrial diseases, age-related conditions, and cardiac disorders, highlighting its significance in advancing medical science.

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SS-31 Pre Mixed Pen 25mg
Price range: £146.81 through £396.39 Select options This product has multiple variants. The options may be chosen on the product page
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SS-31 Peptide Vial
Price range: £113.46 through £297.44 Select options This product has multiple variants. The options may be chosen on the product page
SS-31 Nasal Spray
Price range: £152.23 through £299.46 Select options This product has multiple variants. The options may be chosen on the product page

SS-31 Peptide Netherlands

High purity SS-31 peptide Netherlands is available from PharmaGrade.Store in a number of different products for research use:

- SS-31 Peptide Vial – SS-31 supplied in a sterile glass vial. Please note you also require bacteriostatic water to reconstitute your SS-31 peptide before use.
  Choose from 10mg or 50mg SS-31 Peptide vials here.
- SS-31 Peptide Nasal Spray A ready to use peptide solution for administration via the nasal passage of research subjects – . Choose from 15 ml or 30ml SS-31 nasal sprays here.
- SS-31 Pre-Mixed Peptide Pen – PharmaGrade.Store Peptide pen kits and refill cartridges are pre-mixed and ready to use with SS-31 and Bacteriostatic water. Buy SS-31 Peptide 25mg Pre-Mixed Pen here.

View the full range of peptide accessories and supplies.

Buy SS-31 for Research Purposes

SS-31 peptide, also known as elamipretide, works by directly targeting mitochondrial membranes, specifically binding to cardiolipin, a phospholipid critical for maintaining mitochondrial structure and function [1]. Cardiolipin helps stabilize the inner mitochondrial membrane, but it often becomes oxidized under stress or disease conditions, leading to impaired energy production and cellular damage. SS-31 peptide interacts with cardiolipin, restoring its integrity and preventing oxidative damage triggered by reactive oxygen species (ROS) [2]. Netherlands Research has found that this stabilizing action supports optimal mitochondrial structure, enhances the efficiency of the electron transport chain, and improves ATP production.

By reducing oxidative stress and boosting energy generation, SS-31 peptide mitigates damage to sensitive tissues, particularly in energy-demanding organs like the heart, muscles, and brain [3]. Its ability to enhance mitochondrial resilience has made it a promising candidate for treating mitochondrial disorders, cardiovascular diseases, and age-related conditions.

SS-31 Peptide Benefits

Netherlands In vitro testing has indicated that SS-31 could have the following potential benefits and applications:

Protection against oxidative stress: Reduces oxidative stress by preventing damage caused by reactive oxygen species (ROS) within mitochondria [2].
Enhances mitochondrial function: By stabilizing cardiolipin and improving the efficiency of the electron transport chain, SS-31 may boost ATP production [1].
Protects vital organs: By protecting mitochondrial structure, SS-31 shows significant potential in promoting cellular health and reducing the chances of tissue damage in energy-demanding organs like the heart, brain, and muscles [3].
Potential applications: Shows promise in treating mitochondrial diseases such as Barth syndrome, which involves cardiolipin abnormalities [4]. It also offers potential therapeutic benefits for cardiovascular disorders, including heart failure and ischemia-reperfusion injury, by preserving cardiac mitochondrial integrity [5].
Anti-aging benefits: May slow down age-related decline by combating mitochondrial dysfunction, a key factor in aging processes and associated conditions and neurodegenerative diseases [6].

Scientific Research SS-31 Peptide Netherlands

Netherlands Scientific research on SS-31 peptide has extensively explored its impact on mitochondrial function and oxidative stress reduction [2]. Preclinical and clinical studies have demonstrated its ability to stabilize cardiolipin, enhance ATP production, and protect against mitochondrial damage. Significant breakthroughs include its potential to treat mitochondrial diseases like Barth syndrome and its cardioprotective effects in conditions such as heart failure and ischemia-reperfusion injury [4].

Netherlands Research also highlights its promise in addressing age-related ailments and neurodegenerative disorders by improving mitochondrial resilience [7]. Ongoing studies continue to uncover its therapeutic value, positioning SS-31 as a novel and promising treatment for various energy-deficiency and mitochondrial-related conditions.

SS-31 Specifications:

Molecular Formula: C32H49N9O5

Molecular Weight: 639.8 g/mol

Buy SS-31 Peptide Netherlands online from PharmaGrade.Store today!

Frequently Asked Questions about SS-31 Peptide Netherlands

Is SS-31 classed as an Anti-oxidant?

Yes, SS-31 peptide is classified as an antioxidant. It is a mitochondria-targeted antioxidant that helps reduce mitochondrial reactive oxygen species production and protects against oxidative stress [8].

Can SS-31 reduce inflammation?

Yes, Netherlands research has shown that SS-31 can reduce inflammation. Studies have shown that SS-31 reduces inflammation and oxidative stress by down-regulating Fis1 expression in lipopolysaccharide-stimulated microglia, which suggests its potential in mitigating inflammatory responses.

Can SS-31 peptide assist with the treatment of Diabetes?

SS-31 shows potential in treating diabetes, particularly by addressing mitochondrial health dysfunction associated with the disease. Studies indicate that SS-31 can reduce mitochondrial abnormalities and restore mitochondrial functions in diabetic models. Additionally, it has been observed to increase antioxidant levels and improve cellular functions in Type 2 Diabetes (T2D) patients. These findings suggest that SS-31 may have therapeutic benefits in managing diabetes-related complications.

Is SS-31 approved for human use?

Currently SS-31 is under investigation and has not been approved for human consumption by the FDA. SS-31 is only available from PharmaGrade.Store for use in research environments.

Blogs:

Is SS-31 Effective in Reducing Chronic Inflammation?

This blog explores the potential of SS-31, a research peptide, in reducing chronic inflammation a key factor in diseases like heart disease, diabetes, and neurodegenerative disorders. By protecting mitochondria, reducing oxidative stress, and lowering inflammatory markers, SS-31 shows promise in managing cellular stress and inflammation. While still under research, it offers hope for future therapies targeting chronic inflammation.

Read about SS-31 Effective in Reducing Chronic Inflammation

Understanding the Cardiac Implications of Peptides Use

This blog explores the cardiac effects of peptide use, balancing their therapeutic benefits with potential risks. It examines peptides’ roles in heart health, from managing conditions like heart failure to concerns about arrhythmias and blood pressure. Aimed at health enthusiasts, patients, and clinicians, it emphasizes safety, research, and informed decisions in using peptides for cardiovascular care.

Discover the pros and cons of Peptide Therapy for Cardiac Health

Scientific Research:

[1] Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. JACC Basic Transl Sci. 2019 Apr 29;4(2):147-157.

[2] Zhu Y, Luo M, Bai X, Li J, Nie P, Li B, Luo P. SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease. Oxid Med Cell Longev. 2022 Jun 6;2022:1295509.

[3] Birk AV, Liu S, Soong Y, Mills W, Singh P, Warren JD, Seshan SV, Pardee JD, Szeto HH. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol. 2013 Jul;24(8):1250-61.

[4] Russo S, De Rasmo D, Rossi R, Signorile A, Lobasso S. SS-31 treatment ameliorates cardiac mitochondrial morphology and defective mitophagy in a murine model of Barth syndrome. Sci Rep. 2024 Jun 13;14(1):13655.

[5] Chiao YA, Zhang H, Sweetwyne M, Whitson J, Ting YS, Basisty N, Pino LK, Quarles E, Nguyen NH, Campbell MD, Zhang T, Gaffrey MJ, Merrihew G, Wang L, Yue Y, Duan D, Granzier HL, Szeto HH, Qian WJ, Marcinek D, MacCoss MJ, Rabinovitch P. Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice. Elife. 2020 Jul 10;9:e55513.

[6] Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA. Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nat Rev Endocrinol. 2022 Apr;18(4):243-258.

[7] Shan Z, Wang Y, Qiu T, Zhou Y, Zhang Y, Hu L, Zhang L, Liang J, Ding M, Fan S, Xiao Z. SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop. J Headache Pain. 2023 Jun 5;24(1):65.

[8] Escribano-Lopez I, Diaz-Morales N, Iannantuoni F, Lopez-Domenech S, de Marañon AM, Abad-Jimenez Z, Bañuls C, Rovira-Llopis S, Herance JR, Rocha M, Victor VM. The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes. Sci Rep. 2018 Oct 26;8(1):15862.

Buy SS-31 Peptide Netherlands from PharmaGrade.Store

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